By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)
This publication offers a entire, updated evaluate of the distribution, pharmacology and body structure of principal 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes convey a special pharmacology, distribution and serve as, of which the 5-HT4 receptor has been probably the most intensively studied lately, either from a simple examine viewpoint and as a goal for novel therapeutics.
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Additional resources for 5-HT4 Receptors in the Brain and Periphery
8. King FD. Structure activity relationships of 5-HT3 receptor antagonists. In: King FD, Jones BJ, Sanger GJ, eds. 5-Hydroxytryptamine-3 Receptor Antagonists. Boca Raton: CRC Press, 1994:1-44. 9· Flynn DL, Zabrowski DL, Becker DP et al. SC-53116: The first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. J Med Chern 1992; 35:1486-1489. 10. Gaster LM, King FD. Sertonin 5-HT3 and 5-HT4 receptor antagonists. Med Res Rev 1997; 2:163-214. 11. Craig DA, Clarke DE. Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine4 receptor.
3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guineapig striatal and rat cloned (5-HT 4s and 5 HT 4L) receptors. Neuropharmacol1997; 36:671-679. CHAPTER 2 Molecular Biology of 5- HT4 Receptors Theresa A. Branchek, Nika Adham, Christophe Gerald Introduction S erotonin is a neurotransmitter involved in a plethora of physiological functions exerted through its interaction with numerous receptor subtypes throughout the body. 27 However, molecular biological studies have provided both primary amino acid sequence and signal transduction data for a much larger than anticipated array of serotonin receptor subtypes, comprising seven major families: five 5-HTu three 5-HT 2, one 5-HT3, one 5-HT 4, two 5-HT5, one 5-HT 6 and one 5-HT7 receptor.
C $ ':" K Y !. R. "::> ). :"... ' :.. C: 0 ':' V 1> C $ ':' ':' ":' : ~ C S ':' K Y :.. R 't ':' V :. Y. S C 0 M 0 ~ :. 2: X :. ! X S :> ? E S :. tr:"" t ~ ~ 1 Q 0 s: :I :. r. 0 :::: C' ~ t. T. ~ :;. S-M':'... c. cS-K':",,. o~-tr.. ):. Fig. 2. Alignment of amino acid sequences of the available 5-HT4 receptors. Differences in the human sequences are marked in gray. 48 Cloning of 5- HT4 Receptors from Other Species More recendy, the mouse 5-HT4L receptor has been cloned from cultured collicular neurons13 using PCR amplification.
5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)