By John R. Fozard (auth.), Pier Andrea Borea (eds.)
This e-book "A3 Adenosine Receptors from telephone Biology to Pharmacology and Therapeutics " records the current kingdom of information of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that functionality in body structure and intracellular signaling and are eager about inflammatory responses and mediating telephone proliferation and phone dying.
The A3 receptor is more and more being well-known for its organic roles through the physique, and plenty of A3 receptor ligands have confirmed invaluable in elucidating peripheral and important pathologies. This ebook covers a variety of info together with facts from experiences of theoretical, molecular and mobile pharmacology, sign transduction, integrative body structure, new drug discoveries and medical functions. The publication comprises sections on:
- A3 Adenosine Receptor sign transduction
- Adenosine Receptor medicinal chemistry
- Effects and healing purposes of Adenosine Receptors on tissues and organs
- Adenosine Receptors and inflammatory and auto-immune diseases
- Adenosine Receptors and cancer
The chapters during this e-book conceal either basic technological know-how and proper purposes and supply an authoritative account of the present prestige of the sphere. "A3 Adenosine Receptors from telephone Biology to Pharmacology and Therapeutics" is an up-to-the-minute and scientifically first-class resource of knowledge, appealing to easy and scientific scientists alike.
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Extra info for A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
So, their modulation by using agonists or antagonists represents an interesting pharmacological tool in a variety of diseases (Baraldi et al. 2008). At the present, a number of novel agonists and antagonists are in biological testing for several clinical indications suggesting that A3 adenosine receptors may play a basic pharmacological role. A. Borea () Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, via Fossato di Mortara 17–19, 44100, Ferrara, Italy S.
Pharmacol Rev 49:381–402 Feoktistov I, Polosa R, Holgate ST, Biaggioni I (1998) Adenosine A2B receptors: a novel therapeutic target in asthma? Trends Pharmacol Sci 19:148–153 Fossetta J, Jackson J, Deno G, Fan X, Du KK, Bober L, Soude-Bermejo A, de Bouteiller O, Caux C, Lunn C, Lundell D, Palmer RK (2003) Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Mol Pharmacol 63:342–350 Fozard JR, Carruthers AM (1993a) The cardiovascular effects of selective adenosine A1 and A2 receptor agonists in the pithed rat: no role for glibenclamide-sensitive potassium channels.
1994, 2000). Another significant thermodynamic aspect, which characterizes the membrane receptors is the linearity of the van’t Hoff plots in the temperature range usually investigated (0–35°C) indicating that the heat capacity value (DCp°) of the binding equilibrium is nearly zero, a phenomenon which is not usual in reactions involving biomacromolecules in solution (Sturtevant 1977). For this reason both DH and DS values are independent of temperature and their standard values can be obtained by linear van’t Hoff plots.
A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics by John R. Fozard (auth.), Pier Andrea Borea (eds.)