A Guide to Methods in the Biomedical Sciences by Ronald B. Corley PDF

By Ronald B. Corley

ISBN-10: 0387228446

ISBN-13: 9780387228440

ISBN-10: 0387228454

ISBN-13: 9780387228457

A consultant to tools within the Biomedical Sciences offers a simple description of universal tools utilized in examine. this isn't meant to be a tools publication. fairly, it truly is meant to be a booklet that outlines the aim of the equipment defined, their obstacles and supply replacement methods as acceptable. hundreds of thousands of tools were built within the quite a few biomedical disciplines and people lined during this booklet symbolize the elemental, crucial and most generally used tools in different diverse disciplines.

The historic history (including a few fascinating anecdotes) resulting in the advance of ground-breaking ideas are defined, specially those who considerably complicated the sector of biomedical study. Advances that earned their inventors prestigious Nobel Prizes are emphasized.

The publication is split into six sections, highlighting chosen equipment in protein chemistry, nucleic acids, recombinant DNA know-how (including forensic established methods), antibody-based suggestions, microscopy and imaging, and using animals in biomedical sciences.

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Extra resources for A Guide to Methods in the Biomedical Sciences

Example text

From the development of simple methods to clone, sequence, and manipulate DNA came a realization of its power to help solve the genetic basis of human disease. This, in turn, resulted in the development and evolution of the Biotechnology Industry, an industry that was founded to develop ways to synthesize hormones, enzymes and other proteins, rather than rely on their purification from natural sources. The production of hormones in the laboratory made it practical to treat patients on a large scale for the first time.

For example, matrix-assisted laser desorption/ionization (MALDI) MS, combined with a time-of-flight (TOF) analyzer is referred to as MALDI-TOF MS. A critical concern in MS is that the methods used for ionization can be so harsh that they may generate very little product to measure at the end. The development of “soft” desorption ionization methods by John Fenn and Koichi Tanaka, which allowed the application of MS to biomolecules on a wide scale, earned them a share of the Nobel Prize in Chemistry in 2002.

Using CD spectroscopy in the “near-uv” spectrum (250–350 nm) can sometimes provide some information on the tertiary structure of the protein. CD spectroscopy is also used to measure structural changes that might occur upon the interaction of two proteins, or upon receptor-ligand interactions. X-ray crystallography X-ray crystallography was the first method developed for determining the 3-dimenstional structure of a protein and remains the method of choice for solving the structure of proteins that can be crystallized.

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A Guide to Methods in the Biomedical Sciences by Ronald B. Corley


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