Pinuccia Valagussa (auth.), Monica Castiglione, Martine J.'s Adjuvant Therapy for Breast Cancer PDF

By Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

ISBN-10: 0387751149

ISBN-13: 9780387751146

ISBN-10: 0387751157

ISBN-13: 9780387751153

Adjuvant therapy is run sooner than or as persist with as much as surgeries for breast melanoma. confirmed good fortune in utilizing clinical treatments bearing in mind breast maintaining strategies or lowering threat of incidence. even if there was a lot development in the direction of a treatment, together with the creation of recent unique treatments, metastasizing melanoma continues to be hugely incurable.

"The adjuvant remedy of breast melanoma has develop into usual of care. A spectrum of biologic and prognostic elements are thought of sooner than a healing method is applied. during this textual content prime investigators within the box talk about present administration and significant investigative issues."

Steven T. Rosen, M.D.
Series Editor

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Extra resources for Adjuvant Therapy for Breast Cancer

Sample text

Markers Predicting the Activity of Anti-HER-2 Therapies The identification of patient candidates for anti-HER-2 therapies either in the early or in the metastatic setting is by far the most relevant information provided by HER-2 testing of breast cancer samples. Large phase III trials have unequivocally proved the efficacy of anti-HER-2 agents such as trastuzumab and lapatinib in patients carrying HER-2 positive tumors [79–84]. The identification of molecular markers complementing HER-2 scores with the aim to define better the profile of anti-HER-2 compound sensitive tumors is certainly a relevant research area.

Nano-Particles in Diagnosis and Therapy Nano-particles are very small particles of 1–1,000 nm diameter comprising a core element used for their detection and a shell allowing the interaction with biological systems. The shells of nano-particles are composed of an organic layer made of a variety of components such as polyethyleneglycols, silicon, or albumin (Fig. 3). Tissue-specific ligands such as tumor specific antibodies can be linked to these organic molecules, enabling targeting of the particles to the desired tissue.

Van ’t Veer VI, Dai H, van de Vijer MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530–6. 8. Van de Vijer MJ, He YD, van ‘t Veer VI, et al. A gene expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002;347:1999–2009. 9. Wang Y, Klijn, JG, Zhang Y, et al. Gene expression profiles to predict distant metastases of lymph-node-negative primary breast cancer. Lancet. 2005;365:671–9. 10. Sotiriou C, Wirapati P, Loi S, et al.

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Adjuvant Therapy for Breast Cancer by Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

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