By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober
The diagnostic and healing achievements in radiopharmaceuticals and nuclear drugs instrumentation ? puppy, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT
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Additional info for Advances in Nuclear Oncology:: Diagnosis and Therapy
Thus, if such a technique was sufficiently sensitive and specific, it could allow a non-invasive diagnosis obviating the need for biopsic sampling prior to surgical intervention. 31,32 Detection of a brain lesion is the first diagnostic step in patients with symptoms and signs suggesting the presence of a brain tumor. Imaging is primarily done to prove or rule out the presence of such a lesion. To this end, both direct and indirect signs are sought. A direct sign of a brain tumor is an area with a density (CT) or signal (MRI) different from that of normal cerebral tissue, including changes secondary to contrast media infusion.
21. Turetschek K, Roberts TP, Floyd E et al. Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model. J Magn Reson Imaging 2001; 13: 882–8. 22. Boellaard R, Knaapen P, Rijbroek A, Luurtsema GJ, Lammertsma AA. Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography. Mol Imaging Biol 2005; 7: 273–85. 23. Bruehlmeier M, Roelcke U, Schubiger PA, Ametamey SM.
They can also be non-secreting, and all can cause hormonal misbalances or other symptoms due to the compression of surrounding structures, such as hormonal deficiencies and visual problems due to compression of the optic chiasm. Aids to diagnosis are plasma hormone measurements in addition to MRI of the sella turcica. Pituitary adenomas are typically divided on the basis of their size into ‘microadenomas’ when their size is below 10 mm in diameter and ‘macroadenomas’ when they are bigger. Nearly all of these tumors are benign.
Advances in Nuclear Oncology:: Diagnosis and Therapy by Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober