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By Michael Holt, Cynthia Ju (auth.), Jack Uetrecht (eds.)

ISBN-10: 3642006620

ISBN-13: 9783642006623

This ebook offers the present country of information of uncomplicated mechanisms of inauspicious drug reactions (ADRs). the focus is on idiosyncratic drug reactions simply because they're the main tough to house. It starts off with a basic description of the most important objectives for ADRs by means of an outline of what are shortly believed to be mediators and biochemical pathways fascinated with idiosyncratic drug reactions. there's additionally an outline of a number of examples of ADRs that serve to demonstrate particular features of ADR mechanisms. ultimately the ebook indicates that finally greater tools are had to expect which drug applicants tend to reason ADRs and which sufferers are at elevated possibility. yet at the moment learn appears faraway from this goal.

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Extra info for Adverse Drug Reactions

Example text

2 Acute Generalized Exanthematous Pustulosis (AGEP) . . . . . . . . . . . . . . . . 3 Bullous Exanthema, Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Drug (-Induced) Hypersensitivity Syndrome (DHS or DiHS) or Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) . . . . . . . . . . . . . 5 Multiple Drug Hypersensitivity Syndrome .

2 Acute Generalized Exanthematous Pustulosis (AGEP) . . . . . . . . . . . . . . . . 3 Bullous Exanthema, Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Drug (-Induced) Hypersensitivity Syndrome (DHS or DiHS) or Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) . . . . . . . . . . . . . 5 Multiple Drug Hypersensitivity Syndrome .

1 Stimulation of naı¨ve T Cells (Sensitization Phase) . . . . . . . . . . . . . . . . . . 2 Effector Phase in Immune-Mediated Drug Hypersensitivity . . . . . . . . . . . . . 34 3 Different Types of T Cell-Mediated Drug Hypersensitivity Reactions . . . . . . . . . . . 41 4 Clinical Features and Pathophysiology of Cutaneous Reactions . . . . . . . . . . . . . . 1 Maculopapular Exanthem (MPE) .

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Adverse Drug Reactions by Michael Holt, Cynthia Ju (auth.), Jack Uetrecht (eds.)


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