By M. Kowalski
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Additional info for Allergic Rhinitis
Eur Ann Allergy Clin Immunol 2005;37:147–151. Fiocchi A, Pajno G, La Grutta S, Pezzuto F, Incorvaia C, et al. Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years. Ann Allergy Asthma immunology. 2005;95:254 –258. Flicker S, Valenta R. Renaissance of the blocking antibody concept in type I allergy. Int Arch Allergy Immunol 2003;132:13–24. Frew AJ, Smith HE. Sublingual immunotherapy. J Allergy Clin Immunol 2001;107:441–444. Gabrielsson S, Soderlund A, Paulie S, van der Pouw Kraan TC, Troye- Blomberg M, Rak S.
2007) All these studies, clearly show the efficacy of SLIT in reducing the symptom score during pollen season in children with rhinitis; furthermore, there were also a significant reduction in medication use. The allergens that have been used with success in SLIT in the pediatric age group for rhinitis are pollen from Phleum pratense, 5-grass mix, Parietaria and Betulaceae pollens and HDM. ( Bufe A et al. 2004) 23 DBPC studies in the period of 1990-2002. documented clinical efficacy of SLIT. Pediatric population was involved in 16 of those studies.
G. FcγRII) expressed by B lymphocytes, basophils, or mast cells. FcγRII receptors contain immunoreceptor tyrosine-based inhibitory motifs (ITIM), they transduce, as a consequence, negative signals preventing cellular activation and release of soluble pro-inflammatory mediators following co-aggregation with FcεRI receptors. , 2003) SLIT prevented the recruitment of eosinophils in the eyes or in the nose after allergen challenge. , 2002) SLIT with grass pollen extracts was shown to decrease local or systemic levels of eosinophil cationic protein (ECP), without any increase in tryptase.
Allergic Rhinitis by M. Kowalski